Bacterial peroxidases – Multivalent enzymes that enable the use of hydrogen peroxide for microaerobic and anaerobic proliferation

Bacterial peroxidases are responsible for the reduction of hydrogen peroxide to water. Found in periplasm gram-negative bacteria, they one defense mechanisms against endogenous and exogenous stress under low oxygen tensions. Besides being involved detoxification, bacterial have been proposed constitute an alternative pathway respiratory chain anoxic conditions, as demonstrated E. coli that can use electron acceptor absence oxygen. c-type cytochromes with either two or three hemes bound polypeptide chain, divided into classical non-classical, respectively. Orthologous MauG enzymes share some structural, spectroscopic sequence similarities but distinct physiological roles (though most their function remains unknown). The kinetic data on reviewed both classes. Most require reductive activation consists structural changes so catalytic heme becomes accessible substrate. However, non-classical ready bind center is penta-coordinated, which also observed model. few studies report involvement from pathogenic bacteria biofilms, indication these might contribute infection mechanism thus drug targets.